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Publications & Patents

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Our Work

A collection of books, guest chapters, publications and patents our team has authored or co-authored. 

 
 

Books

Medical Imaging in Clinical Trials. Authors: Colin G Miller, Joel Krasnow, Lawrence H. Schwartz.  Pub by Springer in 2014 (ISBN 978-1-84882-710-3)

Clinical Trials in Rheumatoid and Osteoarthritis. Authors: David Reid and Colin G Miller.  Published by Springer London Ltd. 2008 (ISBN 97811852338749).

Clinical Trials in Osteoporosis. Authors:  Derek Pearson and Colin G Miller. Published by Springer London Ltd. 2002. (ISBN 1852332298) (2nd Edition 2007).

 
 

Guest chapters

Potential measurements in patients with osteoporosis. Miller CG. In Clinical Measurement in Drug Evaluation Edited by W.S. Nimmo and G.T. Tucker 1995, Chapter 4. Wolfe Publishing Ltd.

Instrument quality control and phantoms for DXA scanners. Colin G. Miller pp147-192 in The evaluation of osteoporosis 2nd Edition. 1999. By Blake G, Wahner H, Fogelman I. Published by Martin Dunitz.

The use of bone densitometry in clinical trials.  Colin G. Miller pp387-394.  The evaluation of osteoporosis 2nd Edition. 1999. by Blake G, Wahner H, Fogelman I.  Published by Martin Dunitz.

Ultrasound attenuation in the os calcis. Porter RW, Miller CG, Langton CM, Rogers L, Palmer SB, In Back Pain: New methods for clinical investigation and assessment. Edited by Hukins DWL, Mulholland RC. 1986 Manchester University Press.

The prediction of fracture of the proximal femur by broadband ultrasonic attenuation. Miller CG, Porter RW. In The International Symposium on Osteoporosis, Denmark 1987. Edited by Christiansen C, Johansen JS, Riis BJ.

Broadband ultrasonic attenuation as a predictive index for hip fracture in the elderly. Miller CG, Porter RW. In Ultrasonic Assessment of Bone. Edited by Palmer SB, Langton CM. IOP Publishing Short meeting series No. 6. 1987.

Specificity and sensitivity of ultrasound attenuation in bone. Murray SA, Miller CG, Kanis JA, in Ultrasonic studies of bone. Edited by Palmer SB, Langton CM. IOP Publishing Short meeting series No. 6, 1987.

 
 

Peer-Reviewed Publications

Neurogenic claudication and root claudication treated with calcitonin:  A double-blind trial. Porter RW, Miller CG. Spine 1989; 13(9):1061–4.

Ketorolac transfer into CSF. O' Sullivan GM, Rice ASC, Miller C, Lloyd J, Bullingham RES. European Journal Clinical Pharmacology 1989; 36S.

Assessment of broadband ultrasonic attenuation in the os calcis in vitro. McCloskey EV, Murray SA, Charlesworth D, Miller C, Fordham J, Clifford K, Atkins R, Kanis JA. Clinical Science 1990; 78:221–5.

Broadband ultrasonic attenuation in the os calcis: relationship to bone mineral at other sites. McCloskey EV, Murray SA, Miller C, Charlesworth D, Tindale W, O'Doherty DP, Bickerstaff DR, Hamdy NAT, Kanis JA. Clinical Science 1990; 78:227–33.

Prediction of hip fracture in elderly women:  A prospective study. Miller CG, Porter RW, Grainger D, Palmer SB.  In Osteoporosis 1990. The third international symposium on osteoporosis, Copenhagen, Denmark.  Edited by Christiansen C, Overgaard K.

Prediction of hip fracture in elderly women: A prospective study. Porter RW, Miller CG, Grainger D, Palmer SB. British Medical Journal 1990; 301:638–41.

Prediction of hip fracture in elderly women. Miller CG, Porter RW. British Medical Journal 1991; 302:50 (letter to the editor).

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Bioavailability of two formulations of Naproxen enteric-coated 500 mg tablets in fasting and postprandial male volunteers following a single dose. Miller CG, Bullingham RES, Jonkman JHG. Current Therapeutic Research 1991; 49(5):740–9.

A double-blind study of the speed of onset of analgesia following the intramuscular administration of ketorolac tromethamine in comparison to intramuscular morphine and placebo. Rice ASC, Lloyd J, Miller CG, Bullingham RE, O'Sullivan GM. Anesthesia 1991; 46; 7:541–44.

Ultrasonic measurements in the calcaneus: a comparison of two commercial scanners. Ramalingam T, Herd RJM, Blake GM, Miller CG, Fogelman I. in Current Research in Osteoporosis and Bone Mineral Measurement II: 1992 Ring EFJ Br. Inst Radiol 1992.

Can ultrasonic measurements in the calcaneus predict osteopenia in the axial skeleton? Herd RJM, Blake GM, Miller CG, Fogelman I. in Current Research in Osteoporosis and Bone Mineral Measurement II: 1992. Ring EFJ Br. Inst Radiol 1992.

Ultrasonic velocity measurements through the calcaneus: which velocity should be measured? Miller CG, Herd RJM, Ramalingam T, Blake GM, Fogelman I. in Current Research in Osteoporosis and Bone Mineral Measurement II: 1992 Ring EFJ Br. Inst Radiol 1992.

Ultrasonic velocity measurements through the calcaneus: which velocity should be measured? Miller CG, Herd RJM, Ramalingam T, Blake GM, Fogelman I. Osteoporosis International 1993; 3(1):31-5.

Bone density measurements in clinical trials: the challenge of ensuring optimal data. Miller CG. British Journal of Clinical Research 1993; 4:113-20.

Measurement of postmenopausal bone loss with a new contact ultrasound system. Herd RJM, Blake GM, Ramalingam T, Miller CG, Ryan PJ, Fogelman I. Calcified Tissue International 1993;53(3):153-7.

Should broadband ultrasonic attenuation be normalized for the width of the calcaneus? Herd RJM, Blake GM, Miller CG, Fogelman I. in Current Research in Osteoporosis and Bone Mineral Measurement III: 1994 Ring EFJ Br. Inst Radiol 1994.

Optimal bone density measurements in clinical trials. Miller CG, in Current Research in Osteoporosis and Bone Mineral Measurement III: 1994 Ring EFJ Br. Inst Radiol 1994.

The ultrasonic assessment of osteopenia as defined by dual X-ray absorptiometry. Herd RJM, Blake GM, Miller CG, Parker JC, Fogelman I. British Journal of Radiology 1994; 67(799):631-5.

Entrance criteria for clinical trials with DEXA. Miller CG, Barden HS. Journal of Bone and Mineral Research 1994; 9(Supplement 1):S209.

Cross-calibration of Dual Energy X-ray densitometers for a large, multi-centre genetic study of osteoporosis. Reid DM, Mackay I, Wilkinson S, Miller C, Schuette DG, Compston J, Cooper C, Duncan E, Galwey N, Keen R, Langdahl B, McLellan A, Pols H, Uitterlinden A, Riordan JO, Wass JAH, Ralston SH, Bennett ST. Osteoporosis International 2006;17(1):125-32.

Vertebral morphometry using radiographs: comparison of manual and digitized images in expert software. Miller CG, Ohlsson S, Borg J, Johnell O. Osteoporosis International 1996; 6(Supplement 1).

New DEXA quality control methodology in clinical trials. Miller CG, Lyons AR, Pye D, Fasano G, Horneye S. Journal of Bone and Mineral Research 1997;12(Supplement 1):S5377.

Dual energy x-ray absorptiometry (DXA) transmission methodology in clinical trials. Miller CG, Lyons AR, Pye DW, Blaze M, Fasano GA, Horneye S. Drug Information Journal 1998; 32-4.

A new hydroxyapatite spine phantom. Nord RH, Bisek JP, Miller CG. Osteoporosis International 1997; 7:287.

Heel ultrasound reference data for Caucasian women in the USA. Rosen C, McClung M, Gallagher C, Baldwin D, Faulkner K, Trempe J, Miller C. Journal of Clinical Densitometry. 1998; 1(1):107.

Instrument measurements in clinical trials – presenting the right image. Miller CG. European Pharmaceutical Contractor. May 1998:84-9.

Methodology for the clinical assessment of medical instrumentation: evaluating ultrasonometers. Miller CG. Journal of Clinical Densitometry. 1998; 1(3):309-16.

Cross calibration, precision and patient dose measurements in preparation for clinical trials using dual energy X-ray absorptiometry of the lumbar spine. Cawte SA, Pearson D, Green DJ, Masalanka WB, Miller CG, Rogers AT. British Journal of Radiology. 1999; 72(856):354-62.

Precision of DXA measurements of the spine and total hip in adolescents. Miller CG, Pak J, Caminis JN. Journal of Bone and Mineral Research 2001; 16(Supplement 1):S317.

The use of medical imaging. Miller CG. SoCRA Source November 2001; 30:26-8.

Image Management in Clinical Trials. Miller CG. Business Briefing: Pharmatech 2002.

Scanning data for clinical information. Miller C, Noever K. Good Clinical Practices Journal. 2003. 10(9):21-4.

Reading Medical Images in Oncology Clinical Trials. Miller CG, Noever K. European Pharmaceutical Contractor. Summer 2004; 95-100.

Cross-calibration of Dual Energy X-Ray densitometers for a large multi-centre genetic study of osteoporosis. Reid DM, Mackay I, Wilkinson S, Miller C, Schuette DG, Compston J, Cooper C, Duncan E, Galwey N, Keen R, Langdahl B, McLellan A, Pols H, Uitterlinden A, Riordan JO, Waas JAH, Ralston SH, Bennett SH. Osteoporosis International 2005.

Medical Imaging Core Laboratories. Applied Clinical Trials. Miller CG. 2nd Oct 2005 http://www.appliedclinicaltrialsonline.com/appliedclinicaltrials/author/authorDetail.jsp?id=22742

Visceral and Subcutaneous Adiposity Measurements in Adults: Influence of Measurement Site. Ellis KJ, Grund B, Visnegarwala F, Thackeray L, Miller CG, Chesson CE, El-Sadr W, Carr A. Obesity 2007;15(6):1441-7.

Education Alternatives for imaging techniques in clinical trials. Miller CG, Wertz K. World Pharma Network. July 2007; 42-3.

Same Language, Different Message: The American Way from a British Perspective. Presentation at the Annual Meeting of the Institute of Clinical Research, April 2008 (Birmingham). Pub. CRFocus; June 2008; 19(6):75-6.

Medical imaging and electronic data capture in clinical trials: the future paradigm. Miller CG. International Pharmaceutical Industry (IPI) Spring 2009; 30-32.

Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations. Fisher M, Feuerstein G, Howells et al. Stroke 2009; 40(6):2244-50.

Development of a clinical workflow tool to enhance the detection of vertebral fractures. Brett A, Miller CG, Hayes CW, Krasnow J, Ozanian T, Abrams K, Block J, van Kuijk C. Spine 2009;34(22):2437-43.

Quantitative Imaging Test Approval and Biomarker Qualification: Interrelated but Distinct Activities. Buckler, AJ, Bresolin L, Dunnick NR, Sullivan DC, Aerts HJ, Bendriem B, Bendtsen C, Boellaard R, Boone JM, Cole PE, Conklin JJ, Dorfman GS, Douglas PS, Eidsaunet W, Elsinger C, Frank RA, Gatsonis C, Giger ML, Gupta SN, Gustafson D, Hoekstra OS, Jackson EF, Karam L, Kelloff GJ, Kinahan PE, McLennan G, Miller CG, Mozley PD, Muller KE, Patt R, Raunig D, Rosen M, Rupani H, Schwartz LH, Siegel BA, Sorensen AG, Wahl RL, Waterton JC, Wolf W, Zahlmann G, Zimmerman B. "." Radiology. 2011. 259(3): 875-884.

Mechanism of Action Study to Evaluate the Effect of Rosiglitazone on Bone in Postmenopausal Women with Type 2 Diabetes Mellitus: Rationale, Study Design and Baseline Characteristics. Lorraine A. Fitzpatrick, John P. Bilezikianb, Margaret Wooddell, Gitanjali Paula, Nikheel S. Kolatkara, Antonio J. Ninoa, Colin G. Miller, Cesar E. Bogadof, Claude D. Arnaudg, Alexander R. Cobitza Journal of Drug Assessment 2012 Vol 1; 11-19.

A phase 3 trial of the efficacy and safety of oral recombinant calcitonin: The ORACAL trial. Binkley N, Bolognese M, Sidorowicz-Bialynicka A, Vally T, Trout R, Miller C, Buben CE, Gilligan JP, Krause DS. J Bone Miner Res. 2012 Mar 21. 27(8):1821-1829.

Metrics in Medical Imaging. Changing the picture. HJ Yu, CG Miller, D Flitcraft. Monitor. (Peer reviewed), Aug 2012: 36 – 40.

A 2-Year Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of Oral Selective Inos Inhibitor, Cindunistat, In Patients with Symptomatic Osteoarthritis of the Knee. MP. Hellio Le Graverand, R. Clemmer, P. Redifer, R. Brunell, C.W. Hayes, K. Brandt, S. Abramson, P. Manning, C. Miller, and E Vignon. Ann Rheum Dis. 2012 Nov 10. [Epub ahead of print] PubMed PMID: 23144445.

Considerations when designing a disease-modifying osteoarthritis drug (DMOAD) trial using radiography. Hellio Le Graverand MP, Clemmer RS, Brunell RM, Hayes CW, Miller CG, Vignon E. Semin Arthritis Rheum. 2013 Jan 1. doi:pii: S0049-0172(12)00278-8. 10.1016/j.semarthrit.2012.11.006. [Epub ahead of print] PMID: 23290692.

Rate of adjudication of radiological progression in rheumatoid arthritis randomized controlled trials depending on preset limits of agreement: a pooled analysis from 15 randomized trials. Navarro-Compán V, Landewé R, Ahmad HA, Miller CG, Xu D, Wolterbeek R, van der Heijde D. Rheumatology (Oxford). 2013 Jan 16. [Epub ahead of print] PMID: 23329683.

Rosiglitazone Decreases Bone Mineral Density and Increases Bone Turnover in Postmenopausal Women with Type 2 Diabetes. Mellitus Bilezikian JP, Josse RG, Eastell R, Lewiecki EM, Miller CG, Wooddell M, Northcutt AR, Kravitz BG, Paul G, Cobitz AR, Nino AJ, Fitzpatrick LA. J Clin Endocrinol Metab, April 2013, 98(4):1519–1528.

Measurement error in the assessment of radiographic progression in rheumatoid arthritis (RA) clinical trials: the smallest detectable change (SDC). Navarro-Compán V, van der Heijde D, Ahmad HA, Miller CG, Wolterbeek R, Landewé R. Ann Rheum Dis. 2013 Apr 20. [Epub ahead of print] PMID: 23606704.

Atlas-Based Liver Segmentation and Hepatic Fat-Fraction Assessment for Clinical Trials. Yan, Z, Zhang, S., Tan, C., Belaroussi, B, Yu, H.J., Miller C., Metaxas, D. Computerized Medical Imaging and Graphics, 2014.

Imaging of cartilage and bone: promises and pitfalls in clinical trials of osteoarthritis. Eckstein F., Guermazi A., Gold G., Duryea J., Hellio Le Graverand MP., Wirth W., Miller CG. Osteoarthritis and Cartilage. 22(10):1516-32. doi: 10.1016/j.joca.2014.06.023. PMID: 25278061 [PubMed - in process] Free PMC Article. Oct 2014.

The current status of imaging in anti-NGF clinical trials. Miller, C.G., Guermazi, A., Roemer, F.W. Osteoarthritis and Cartilage, Imaging Atlas for Anti Nerve Growth Factor (a-NGF) Studies, Volume 23, S3 - S7. doi: 10.1016/j.joca.2014.09.002. Jan 2015.

Imaging atlas for eligibility and on-study safety of potential knee adverse events in anti-NGF studies (Part 1). Roemer, F.W., Hayes, C.W., Miller, C.G., Hoover, K., Guermazi, A. Osteoarthritis and Cartilage, Imaging Atlas for Anti Nerve Growth Factor (a-NGF) Studies, Volume 23, S22 - S42. doi: 10.1016/j.joca.2014.09.002. Jan 2015.

Imaging atlas for eligibility and on-study safety of potential hip adverse events in anti-NGF studies (Part 2). Roemer, F.W., Hayes, C.W., Miller, C.G., Hoover, K., Guermazi, A. Osteoarthritis and Cartilage, Imaging Atlas for Anti Nerve Growth Factor (a-NGF) Studies, Volume 23, S43 - S58. doi: 10.1016/j.joca.2014.09.002. Jan 2015.

Imaging atlas for eligibility and on-study safety of potential shoulder adverse events in anti-NGF studies (Part 3). Roemer, F.W., Hayes, C.W., Miller, C.G., Hoover, K., Guermazi, A. Osteoarthritis and Cartilage, Imaging Atlas for Anti Nerve Growth Factor (a-NGF) Studies, Volume 23, S59 - S68. doi: 10.1016/j.joca.2014.09.002. Jan 2015.

A double-blind, randomized, Phase III, multicenter study in 358 pediatric subjects receiving isotretinoin therapy demonstrates no effect on pediatric bone mineral density. K B Hoover, C G Miller, N C Galante, C B Langman. Osteoporosis International. Doi: 10.1007/s00198-015-3158-2 May 2015

A DXA whole body composition cross-calibration experience: Evaluation with humans, spine and whole Body phantoms. D. Krueger, J. Libber, J. Sanfilippo, H-J. Yu, B. Horvath, C.G. Miller, N. Binkley. Journal of Clinical Densitometry, doi: org/10.1016/j.jocd.2015.04.003 June 2015

OARSI Clinical Trials Recommendations: Hip imaging in clinical trials in osteoarthritis. G E Gold, F Cicuttini, M D Crema, F Eckstein, A Guermazi, R Kijowski, T M Link, E Maheu, J Martel-Pelletier, C G Miller, J-P Pelletier, C G Peterfy, H G Potter, F W Roemer, D J Hunter Osteoarthritis and Cartilage. DOI:10.1016/j.joca.2015.03.004 May 2015; 23(5):716-731

OARSI Clinical Trials Recommendations: Knee imaging in clinical trials in osteoarthritis. D J Hunter, RD Altman, F Cicuttini, M D Crema, J Duryea, F Eckstein, A Guermazi, R. Kijowski, TM Link, , J Martel-Pelletier, C G Miller, TJ Mosher, R E Ochoa-Albíztegui, J-P Pelletier, C Peterfy, J-P Raynauld, F Roemer, SM Totterman, G E Gold. Osteoarthritis and Cartilage. DOI:10.1016/j.joca.2015.03.004 · May 2015; 23(5):698-715

OARSI Clinical Trials Recommendations: Hand imaging in clinical trials in osteoarthritis. D J Hunter, N Arden, F Cicuttini, M D Crema, B Dardzinski, J Duryea, A Guermazi, I K Haugen, M Kloppenburg, E Maheu, C G Miller, J Martel-Pelletier, R E Ochoa-Albíztegui, J-P Pelletier, C Peterfy, F Roemer, G E Gold. Osteoarthritis and Cartilage. DOI:10.1016/j.joca.2015.03.003 May 2015; 23(5):732-746

A DXA Whole Body Composition Cross-Calibration Experience: Evaluation With Humans, Spine, and Whole Body Phantoms. Diane Krueger, Jessie Libber, Jennifer Sanfilippo, Hui Jing Yu, Blaine Horvarth, Colin G Miller, Neil Binkley. J Clinical Densitometry April 2016 19(2) 220-225

Evaluation of Quantitative Computed Tomography Cortical Hip Quadrant in a Clinical Trial With Rosiglitazone: A Potential New Study Endpoint. Colin G Miller, Cesar C Bogado, Antonio J Nino, Allison R Northcutt, Hui Jing Yu, E Michael Lewicki, G Paul, Alexander R Cobitz, Margaret J Woodall, John P Belizikian, Lorraine A Fitzpatrick. J Clinical Densitometry 2016. http://dx.doi.org/10.1016/j.jocd.2016.02.003

Development of an imaging mitigation strategy for patient enrolment in the Tanezumab nerve growth factor inhibitor (NGF-ab) program with a focus on eligibility assessment. Frank W. Roemer, Colin G. Miller, Christine R. West, Mark T. Brown, Sarah P. Sherlock, Andrew J. Kompel, Luis Diaz, Nicholas Galante, Michel D. Crema, Ali Guermazi. Journal: Seminars in Arthritis and Rheumatism. May 2017. http://dx.doi.org/10.1016/j.semarthrit.2017.05.008

Adherence to Follow-up Recommendations Among Individuals in the Philadelphia Glaucoma Detection and Treatment Project. Hark LA, Leiby BE, Waisbourd M, Myers JS, Fudemberg SJ, Mantravadi AV, Dai Y, Gilligan JP, Resende AF, Katz LJ. J Glaucoma. 2017 Aug;26(8):697-701. doi: 10.1097/IJG.0000000000000716. PubMed PMID: 28671920.

The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists. Thomas S, Izard J, Walsh E, Batich K, Chongsathidkiet P, Clarke G, Sela DA, Muller AJ, Mullin JM, Albert K, Gilligan JP, DiGuilio K, Dilbarova R, Alexander W, Prendergast GC. Cancer Res. 2017 Apr 15;77(8):1783-1812. doi: 10.1158/0008-5472.CAN-16-2929. Epub 2017 Mar 14. Review. PubMed PMID: 28292977; PubMed Central PMCID: PMC5392374.

Does salmon calcitonin cause cancer? A review and meta-analysis. Wells G, Chernoff J, Gilligan JP, Krause DS. Osteoporos Int. 2016 Jan;27(1):13-9. doi: 10.1007/s00198-015-3339-z. Epub 2015 Oct 5. Review. PubMed PMID: 26438308; PubMed Central PMCID: PMC4715844.

Efficacy and safety of oral recombinant calcitonin tablets in postmenopausal women with low bone mass and increased fracture risk: a randomized, placebo-controlled trial. Binkley N, Bone H, Gilligan JP, Krause DS. Osteoporos Int. 2014 Nov;25(11):2649-56. doi: 10.1007/s00198-014-2796-0. Epub 2014 Jul 16. PubMed PMID: 25027109; PubMed Central PMCID: PMC4203997.

The calcitonin and glucocorticoids combination: mechanistic insights into their class-effect synergy in experimental arthritis. Al-Kashi A, Montero-Melendez T, Moradi-Bidhendi N, Gilligan JP, Mehta N, Perretti M. PLoS One. 2013;8(2):e54299. doi: 10.1371/journal.pone.0054299. Epub 2013 Feb 5. PubMed PMID: 23393556; PubMed Central PMCID: PMC3564948.

A phase 3 trial of the efficacy and safety of oral recombinant calcitonin: the Oral Calcitonin in Postmenopausal Osteoporosis (ORACAL) trial. Binkley N, Bolognese M, Sidorowicz-Bialynicka A, Vally T, Trout R, Miller C, Buben CE, Gilligan JP, Krause DS; Oral Calcitonin in Postmenopausal Osteoporosis (ORACAL) Investigators. J Bone Miner Res. 2012 Aug;27(8):1821-9. doi: 10.1002/jbmr.1602. PubMed PMID: 22437792.

Calcitonin for osteoporosis and bone pain. Mehta NM, Malootian A, Gilligan JP. Curr Pharm Des. 2003;9(32):2659-76. Review. PubMed PMID: 14529539.

Biopharmaceutical approaches for developing and assessing oral peptide delivery strategies and systems: in vitro permeability and in vivo oral absorption of salmon calcitonin (sCT). Sinko PJ, Lee YH, Makhey V, Leesman GD, Sutyak JP, Yu H, Perry B, Smith CL, Hu P, Wagner EJ, Falzone LM, McWhorter LT, Gilligan JP, Stern W. Pharm Res. 1999 Apr;16(4):527-33. PubMed PMID: 10227707.

Effects of calcitonin gene-related peptide on bone turnover in ovariectomized rats. Valentijn K, Gutow AP, Troiano N, Gundberg C, Gilligan JP, Vignery A. Bone. 1997 Sep;21(3):269-74. PubMed PMID: 9276092.

Utility of pharmacodynamic measures for assessing the oral bioavailability of peptides. 1. Administration of recombinant salmon calcitonin in rats. Sinko PJ, Smith CL, McWhorter LT, Stern W, Wagner E, Gilligan JP. J Pharm Sci. 1995 Nov;84(11):1374-8. PubMed PMID: 8587058.

Modulation of carrageenan-induced hind paw edema by substance P. Inflammation. Gilligan JP, Lovato SJ, Erion MD, Jeng AY. 1994 Jun;18(3):285-92. PubMed PMID:7522223.

Production of recombinant salmon calcitonin by in vitro amidation of an Escherichia coli produced precursor peptide. Ray MV, Van Duyne P, Bertelsen AH, Jackson-Matthews DE, Sturmer AM, Merkler DJ, Consalvo AP, Young SD, Gilligan JP, Shields PP. Biotechnology (N Y). 1993 Jan;11(1):64-70. PubMed PMID: 7763486.

Accumulation of pepstatin in cultured endothelial cells and its effect on endothelial processing. Shields PP, Gonzales TA, Charles D, Gilligan JP, Stern W. Biochem Biophys Res Commun. 1991 Jun 28;177(3):1006-12. PubMed PMID: 2059194.

Modulation of endogenous levels of substance P in rat CNS tissues by N,N-diethyldithiocarbamate. Gilligan JP, Lovato SJ, Jeng AY. Ann N Y Acad Sci.1991;632:394-5. PubMed PMID: 1719885.

A radioimmunoassay for measuring alpha-amidating enzyme activity. Jeng AY, Wong M, Lovato SJ, Erion MD, Gilligan JP. Anal Biochem. 1990 Mar;185(2):213-9. PubMed PMID: 1692669.

Rat vascular tissue contains a neutral endopeptidase capable of degrading atrial natriuretic peptide. Tamburini PP, Koehn JA, Gilligan JP, Charles D, Palmesino RA, Sharif R, McMartin C, Erion MD, Miller MJ. J Pharmacol Exp Ther. 1989 Dec;251(3):956-61. PubMed PMID: 2532252.

Multiple forms of peptidyl alpha-amidating enzyme: purification from rat medullary thyroid carcinoma CA-77 cell-conditioned medium. Gilligan JP, Lovato SJ, Mehta NM, Bertelsen AH, Jeng AY, Tamburini PP. Endocrinology. 1989 Jun;124(6):2729-36. PubMed PMID: 2721443.

Structure-activity relationships for glycine-extended peptides and the alpha-amidating enzyme derived from medullary thyroid CA-77 cells. JP, Wennogle LP, Erion M, Jeng AY. Arch Biochem Biophys. 1988 Dec;267(2):623-31. PubMed PMID: 3145718.

Purification of a peptidylglycine alpha-amidating enzyme from transplantable rat medullary thyroid carcinomas. Mehta NM, Gilligan JP, Jones BN, Bertelsen AH, Roos BA, Birnbaum RS. Arch Biochem Biophys. 1988 Feb 15;261(1):44-54. PubMed PMID: 3341777.

A fluorometric assay for peptidyl alpha-amidation activity using high-performance liquid chromatography. Jones BN, Tamburini PP, Consalvo AP, Young SD, Lovato SJ, Gilligan JP, Jeng AY, Wennogle LP. Anal Biochem. 1988 Feb 1;168(2):272-9. PubMed PMID: 3364727.

Effect of removal of atherogenic diet on protein synthesis and cholesterol retention in rabbit aorta and lung. Gilligan JP, Langner RO. Atherosclerosis. 1985 Jan;54(1):1-10. PubMed PMID: 3994775.

Synthesis of collagen in cardiac and vascular walls. Gilligan JP, Spector S. Hypertension. 1984 Nov-Dec;6(6 Pt 2):III44-9. Review. PubMed PMID: 6240453.

o-Phthaldialdehyde precolumn derivatization and reversed-phase high-performance liquid chromatography of polypeptide hydrolysates and physiological fluids. Jones BN, Gilligan JP. J Chromatogr. 1983 Aug 26;266:471-82. PubMed PMID: 6630358.

Early exposure to naloxone increases blood pressure in normotensive and hypertensive rats. Hahn EF, Martucci CP, Gilligan JP, Spector S. Biochem Biophys Res Commun. 1982 Jul 30;107(2):707-13. PubMed PMID: 7126236.

The effect of cholesterol feeding on protein synthesis in different regions of the rabbit arterial wall. Langner RO, Gilligan JP, Ehrhart LA. Exp Mol Pathol. 1979 Oct;31(2):308-17. PubMed PMID: 467620.

 

Patents

A calcium hydroxyapatite phantom for dual energy x-ray absorptiometry instruments.

Variable composition phantom for assessment of body composition for dual energy x-ray absorptiometry instruments. US6315447B1  Nord, RH, Miller, CG.

Digitized image e.g. x-ray image, characterizing method for mammalian spine, involves automatically characterizing target vertebra based on model parameters during runtime phase, and outputting characterization of vertebra on display device. Granted patent number is US8126249B2
AN US2009297012-A1; WO2009154977-A1  AE Brett A; Haslam J; Hayes C, Krasnow J, Miller C, van Kuijk C.

Spine phantom simulating cortical and trabecular bone for calibration of dual energy x-ray bone densitometers. US6302582B1 Nord, RH, Miller, CG.

Oral peptide pharmaceutical products. US-6086918-A William Stern, James P. Gilligan

α-amidation enzyme. US-4708934-A James P. Gilligan, Barry N. Jones

Alpha-amidating enzyme compositions and processes for their production and use. EP-0308067-A2 James P. Gilligan, Barry N. Jones, Nozer M. Mehta, Arthur H. Bertelsen

Expression systems for amidating enzyme. US-5789234-A Arthur H. Bertelsen, Nozer M. Mehta, Gary Agide Beaudry, James P. Gilligan, Barry N. Jones

Improved oral delivery of peptides. WO-2004064758-A2 Nozer M. Mehta, William Stern, James P. Gilligan

Method for fostering bone formation and preservation. US-7648965-B2 Agnes Vignery, Nozer M. Mehta, James P. Gilligan

Method for fostering bone formation and preservation. US-7648700-B2 Agnes Vignery, Nozer M. Mehta, James P. Gilligan

Treatment for obesity. US-2010311650-A1 Nozer M. Mehta, Amy Sturmer, William Stern, James P. Gilligan

Enzymatic reactions in the presence of keto acids. US-7445911-B2 Angelo P. Consalvo, Nozer M. Mehta, William Stern, James P. Gilligan

Oral delivery of peptide pharmaceutical compositions. US-8835377-B2 Nozer M. Mehta, William Stern, James P. Gilligan

Calcitonin products and therapies for treating inflammatory or degenerative diseases. US-2012071410-A1 Nozer M. Mehta, James P. Gilligan

Bone implant device and methods of using same. WO-2006124708-A1 Agnes Vignery, Nozer M. Mehta, James P. Gilligan

Methods and compositions for fostering and preserving bone growth. US-2008213333-A1 Agnes Vignery, Nozer M. Mehta, James P. Gilligan, Keiran P. Murphy

Herbal supplement. WO-2010148394-A1 Agnes P. Olszewski, James P. Gilligan

Method for fostering bone formation and preservation. WO-2006124062-A1 Agnes Vignery, Nozer M. Mehta, James P. Gilligan

Methods and compositions for fostering and preserving bone growth. WO-2008133618-A1 Agnes Vignery, Nozer M. Mehta, James P. Gilligan, Kieran P. Murphy

Oral pharmaceutical products with peptides. DK-0929270-T3 William Stern, James P Gilligan

Room temperature stable oral calcitonin formulation. WO-2018026993-A1 James P. Gilligan, George R. MAURER, Aniruddha M. Railkar, Thomas A. DAGGS, Paul P. SHIELDS, Phil BAUER

Alpha amidating enzyme-coding DNA sequence, host cells and a method for producing an amidated peptides. FI-110433-B James P Gilligan, Barry N Jones, Arthur H Bertelsen, Nozer M Mehta