CONSULTANT PUBLICATIONS

Brad Wyman

PhD

 

PUBLICATIONS

  1. R. Vandenberghe, J. O. Rinne, M. Boada, S. Katayama, P. Scheltens, B. Vellas, M. Tuchman, A. Gass, J. B. Fiebach, and D. Hill, “Bapineuzumab for mild to moderate Alzheimer’s disease in two global, randomized, phase 3 trials,” Alzheimer’s Research & Therapy, vol. 8, no. 1, p. 1, 2016.
  2.  C. Sadowsky, G. P. L. Le, K. Booth, Y. Peng, K. Marek, N. Ketter, E. Liu, B. Wyman, N. Jackson, and M. Slomkowski, “Vanutide Cridificar (ACC-001) and QS-21 Adjuvant in Individuals with Early Alzheimer’s Disease: Amyloid Imaging Positron Emission Tomography and Safety Results from a Phase 2 Study.,” The journal of prevention of Alzheimer’s disease, vol. 3, no. 2, pp. 75–84, 2016.
  3. G. Novak, N. Fox, S. Clegg, C. Nielsen, S. Einstein, Y. Lu, I. C. Tudor, K. Gregg, J. Di, and P. Collins, “Changes in brain volume with bapineuzumab in mild to moderate Alzheimer’s disease,” Journal of Alzheimer’s Disease, vol. 49, no. 4, pp. 1123–1134, 2016.
  4. R. Korn, B. Gburek, A. Woodruff, N. Verma, D. Siebenkaess, B. Wyman, C. Wright, P. Masci, and J. Keppler, “Histopathologic Features that Influence the Detection of Occult Lymph Node Metastasis Using PET/CT Imaging with Anti-PSMA 89Zr-Df-IAB2M in Newly Diagnosed High Risk Prostate Cancer Patients,” Journal of Nuclear Medicine, vol. 57, no. supplement 2, pp. 1544–1544, 2016.
  5. P. G. Conaghan, M. Østergaard, M. A. Bowes, C. Wu, T. Fuerst, D. van der Heijde, F. Irazoque-Palazuelos, O. Soto-Raices, P. Hrycaj, and Z. Xie, “Comparing the effects of tofacitinib, methotrexate and the combination, on bone marrow oedema, synovitis and bone erosion in methotrexate-naive, early active rheumatoid arthritis: results of an exploratory randomised MRI study incorporating semiquantitative and quantitative techniques,” Annals of the rheumatic diseases, vol. 75, no. 6, pp. 1024–1033, 2016.
  6. J. Sun, X.-Q. Zhao, N. Balu, D. S. Hippe, T. S. Hatsukami, D. A. Isquith, K. Yamada, M. B. Neradilek, G. Cantón, and Y. Xue, “Carotid magnetic resonance imaging for monitoring atherosclerotic plaque progression: a multicenter reproducibility study,” The international journal of cardiovascular imaging, vol. 31, no. 1, pp. 95–103, 2015.
  7. K. Subburaj, R. B. Souza, B. T. Wyman, M. H. Le Graverand‐Gastineau, X. Li, T. M. Link, and S. Majumdar, “Changes in MR relaxation times of the meniscus with acute loading: an in vivo pilot study in knee osteoarthritis,” Journal of Magnetic Resonance Imaging, vol. 41, no. 2, pp. 536–543, 2015.
  8. E. Liu, M. E. Schmidt, R. Margolin, R. Sperling, R. Koeppe, N. S. Mason, W. E. Klunk, C. A. Mathis, S. Salloway, and N. C. Fox, “Amyloid-β 11C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials,” Neurology, vol. 85, no. 8, pp. 692–700, 2015.
  9. B. L. Klaassens, H. C. van Gorsel, N. Khalili-Mahani, J. van der Grond, B. T. Wyman, B. Whitcher, S. A. Rombouts, and J. M. van Gerven, “Single-dose serotonergic stimulation shows widespread effects on functional brain connectivity,” NeuroImage, vol. 122, pp. 440–450, 2015.
  10. P. Conaghan, M. Østergaard, M. Bowes, C. Wu, T. Fuerst, D. van der Heijde, P. Hrycaj, Z. Xie, R. Zhang, and B. Wyman, “SAT0222 Effects of Tofacitinib on MRI Endpoints in Methotrexate-Naive Early Rheumatoid Arthritis: A Phase 2 MRI Study with Semi-Quantitative and Quantitative Endpoints,” Annals of the Rheumatic Diseases, vol. 74, no. Suppl 2, pp. 738–738, 2015.
  11. E. Liu, A. Ashaye, K. Travers, L. Strand, K. Olsson, G. L. Tanna, B. T. Wyman, K. Booth, S. Styren, and R. H. Brashear, “A PROSPECTIVE, SYSTEMATIC LITERATURE REVIEW AND META-ANALYSES TO EVALUATE GLOBAL AND REGIONAL BRAIN VOLUMES BY STRUCTURAL MRI AS BIOMARKERS OF ALZHEIMER’S DISEASE (AD) PROGRESSION,” Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, vol. 10, no. 4, p. P354, 2014.
  12. E. Liu, A. Ashaye, K. Travers, L. Strand, G. L. Tanna, B. T. Wyman, K. Booth, S. Styren, R. Brashear, and R. Margolin, “A PROSPECTIVE, SYSTEMATIC LITERATURE REVIEW AND META-ANALYSES TO EVALUATE BRAIN AMYLOID BY POSITRON EMISSION TOMOGRAPHY (PET) IMAGING AS A BIOMARKER OF ALZHEIMER’S DISEASE (AD) PROGRESSION,” Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, vol. 10, no. 4, pp. P353–P354, 2014.
  13. P. G. Conaghan, M. Østergaard, C. Wu, D. Van Der Heijde, F. Irazoque-Palazuelos, P. Hrycaj, Z. Xie, R. Zhang, B. Wyman, and J. Bradley, “Effects of Tofacitinib on bone marrow edema, synovitis, and erosive damage in Methotrexate-naïve patients with early active rheumatoid arthritis (duration≤ 2 years): Results of an exploratory phase 2 MRI study,” Arthritis and Rheumatology, vol. 66, no. Suppl. 11, 2014.
  14. B. T. Wyman, D. J. Harvey, K. Crawford, M. A. Bernstein, O. Carmichael, P. E. Cole, P. K. Crane, C. DeCarli, N. C. Fox, and J. L. Gunter, “Standardization of analysis sets for reporting results from ADNI MRI data,” Alzheimer’s & Dementia, vol. 9, no. 3, pp. 332–337, 2013.
  15. D. van der Heijde, Y. Tanaka, R. Fleischmann, E. Keystone, J. Kremer, C. Zerbini, M. H. Cardiel, S. Cohen, P. Nash, and Y. Song, “Tofacitinib (CP‐690,550) in patients with rheumatoid arthritis receiving methotrexate: twelve‐month data from a twenty‐four–month phase III randomized radiographic study,” Arthritis & Rheumatism, vol. 65, no. 3, pp. 559–570, 2013.
  16. K. Subburaj, R. Souza, B. Wyman, X. Li, T. Link, and S. Majumdar, “Changes in MR relaxation times of the meniscal body with loading: an in vivo pilot study in knee osteoarthritis,” Osteoarthritis and Cartilage, vol. 21, p. S213, 2013.
  17. S. Salloway, R. Sperling, K. Gregg, P. Yu, A. Joshi, M. Lu, M. Mintun, M. Pontecorvo, K. Booth, and B. Wyman, “P4–417: Incidence and clinical progression of placebo‐treated amyloid‐negative subjects with mild‐to‐moderate Alzheimer’s disease (AD): Results from the phase III PET substudies of bapineuzumab and solanezumab,” Alzheimer’s & Dementia, vol. 9, pp. P888–P889, 2013.
  18. G. Novak, S. Einstein, I. C. Tudor, K. Gregg, P. Collins, B. Wyman, E. Yuen, C. Nielsen, M. Grundman, and R. H. Brashear, “The rate of clinical progression and brain atrophy is greater with increasing severity of Alzheimer’s disease: Results from the volumetric MRI substudies of two phase III trials with bapineuzumab,” Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, vol. 9, no. 4, p. P287, 2013.
  19. G. Novak, S. Einstein, Y. Lu, I. C. Tudor, K. Gregg, P. Collins, B. Wyman, E. Yuen, C. Nielsen, and M. Grundman, “Correlation of brain atrophy with clinical progression in mild-to-moderate Alzheimer’s disease: Results from the volumetric MRI substudies of two phase III trials with bapineuzumab,” Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, vol. 9, no. 4, p. P289, 2013.
  20. M. Marsh, R. Souza, B. Wyman, M.-P. H. Le Graverand, K. Subburaj, T. Link, and S. Majumdar, “Differences between X-ray and MRI-determined knee cartilage thickness in weight-bearing and non-weight-bearing conditions,” Osteoarthritis and Cartilage, vol. 21, no. 12, pp. 1876–1885, 2013.
  21. R. Margolin, M. Schmidt, K. Gregg, A. Les, D. Hill, R. Koeppe, B. Wyman, S. Styren, M. Grundman, and E. Yuen, “Evaluation of the pons as a reference region for amyloid PET in Alzheimer’s disease clinical trials,” Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, vol. 9, no. 4, p. P18, 2013.
  22. R. Margolin, N. Ketter, S. Guthrie, D. Deegan, L. Baher, R. Tschopp, K. Marek, J. Seibyl, G. Novak, and J. Streffer, “Biomarker strategy for enrichment and monitoring of biological effect in ACCTION, a phase II study of ACC-001 (vanutide cridificar) for Alzheimer’s disease,” Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, vol. 9, no. 4, pp. P289–P290, 2013.
  23. S. Cotofana, B. Wyman, O. Benichou, D. Dreher, M. Nevitt, J. Gardiner, W. Wirth, W. Hitzl, C. Kwoh, and F. Eckstein, “Relationship between knee pain and the presence, location, size and phenotype of femorotibial denuded areas of subchondral bone as visualized by MRI,” Osteoarthritis and Cartilage, vol. 21, no. 9, pp. 1214–1222, 2013.
  24. R. Buck, E. Katz, Z. Xie, and B. Wyman, “Ordered values of subregional brain volumes improve the detection of disease progression in longitudinal studies of Alzheimer’s disease: Data from ADNI,” Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, vol. 9, no. 4, p. P76, 2013.
  25. B. Wyman, Y. Peng, K. Lobello, G. Zubal, M. Ryan, K. Marek, J. Seibyl, and M. Slomkowski, “Comparison of visual and quantitative florbetapir-PET reads in subjects with early Alzheimer’s disease for assessing amyloid burden,” Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, vol. 8, no. 4, pp. P38–P39, 2012.
  26. D. van der Heijde, Y. Tanaka, R. Fleischmann, E. Keystone, J. Kremer, C. Zerbini, M. Cardiel, S. Cohen, P. Nash, and Y. Song, “Tofacitinib, an Oral Janus Kinase Inhibitor, in Combination with Methotrexate Reduced the Progression of Structural Damage in Patients with Rheumatoid Arthritis: Year 2 Efficacy and Safety Results From a 24-Month Phase 3 Study.: 1277,” Arthritis & Rheumatism, vol. 64, 2012.
  27. R. Sukkar, E. Katz, Y. Zhang, D. Raunig, and B. T. Wyman, “Disease progression modeling using hidden Markov models,” 2012, pp. 2845–2848.
  28. K. Subburaj, R. Souza, C. Stehling, B. Wyman, M. Le Graverand‐Gastineau, T. Link, X. Li, and S. Majumdar, “Association of MR relaxation and cartilage deformation in knee osteoarthritis,” Journal of Orthopaedic Research, vol. 30, no. 6, pp. 919–926, 2012.
  29. C. Stehling, R. B. Souza, M.-P. H. Le Graverand, B. T. Wyman, X. Li, S. Majumdar, and T. M. Link, “Loading of the knee during 3.0 T MRI is associated with significantly increased medial meniscus extrusion in mild and moderate osteoarthritis,” European journal of radiology, vol. 81, no. 8, pp. 1839–1845, 2012.
  30. Y. Peng, B. Wyman, K. Lobello, G. Zubal, M. Ryan, K. Marek, J. Seibyl, and M. Slomkowski, “Comparison of visual and quantitative florbetapir-PET reads in subjects with early Alzheimer’s disease for assessing amyloid burden,” Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, vol. 8, no. 4, pp. P454–P455, 2012.
  31. A. Lang, B. Liu, B. Wyman, B. Caffo, Y. Zhang, E. Katz, P. Jedynak, J. Prince, and B. Jedynak, “Time-dependent changes of 9 biomarkers related to Alzheimer’s disease,” Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, vol. 8, no. 4, pp. P612–P613, 2012.
  32. B. M. Jedynak, A. Lang, B. Liu, E. Katz, Y. Zhang, B. T. Wyman, D. Raunig, C. P. Jedynak, B. Caffo, and J. L. Prince, “A computational neurodegenerative disease progression score: Method and results with the Alzheimer’s disease neuroimaging initiative cohort,” Neuroimage, vol. 63, no. 3, pp. 1478–1486, 2012.
  33. B. Jedynak, B. Liu, A. Lang, B. Caffo, B. Wyman, E. Katz, Y. Zhang, P. Jedynak, and J. Prince, “Sample size comparisons in ADNI: A case for the Alzheimer’s Disease Progression Scale,” Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, vol. 8, no. 4, pp. P613–P614, 2012.
  34. L. Bracoud, B. Belaroussi, K. Lobello, D. Li, H. J. Yu, C. Pachai, and B. Wyman, “Correlation between DWI-ADC and clinical scores in mild-to-moderate Alzheimer’s disease,” Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, vol. 8, no. 4, pp. P118–P119, 2012.
  35. L. Bracoud, B. Belaroussi, K. Lobello, D. Li, H. J. Yu, C. Pachai, and B. Wyman, “Correlation between diffusion weighted imaging-apparent diffusion coefficient and clinical scores in mild-to-moderate Alzheimer’s disease,” Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, vol. 8, no. 4, p. P74, 2012.
  36. W. Wirth, S. Larroque, R. Y. Davies, M. Nevitt, A. Gimona, F. Baribaud, J. H. Lee, O. Benichou, B. T. Wyman, and M. Hudelmaier, “Comparison of 1-year vs 2-year change in regional cartilage thickness in osteoarthritis results from 346 participants from the Osteoarthritis Initiative,” Osteoarthritis and cartilage, vol. 19, no. 1, pp. 74–83, 2011.
  37. R. Sukkar, B. Wyman, E. Katz, Y. Zhang, and D. Raunig, “Modeling Alzheimer’s disease progression using hidden markov models,” Alzheimer’s & Dementia, vol. 7, no. 4, p. S147, 2011.
  38. K. Subburaj, R. Souza, C. Stehling, B. Wyman, M. H. Le Graverand-Gastineau, T. Link, X. Li, and S. Majumdar, “Association of MR Relaxation Times and Functional Behavior of Osteoarthritic Cartilage using Loaded Knee MRI,” 2011, vol. 19, p. 3238.
  39. R. Stahl, S. K. Jain, J. Lutz, B. T. Wyman, M.-P. H. Le Graverand-Gastineau, E. Vignon, S. Majumdar, and T. M. Link, “Osteoarthritis of the knee at 3.0 T: comparison of a quantitative and a semi-quantitative score for the assessment of the extent of cartilage lesion and bone marrow edema pattern in a 24-month longitudinal study,” Skeletal radiology, vol. 40, no. 10, pp. 1315–1327, 2011.
  40. C. S. Shin, R. B. Souza, D. Kumar, T. M. Link, B. T. Wyman, and S. Majumdar, “In vivo tibiofemoral cartilage‐to‐cartilage contact area of females with medial osteoarthritis under acute loading using MRI,” Journal of Magnetic Resonance Imaging, vol. 34, no. 6, pp. 1405–1413, 2011.
  41. F. Eckstein, M. H. Le Graverand, H. Charles, D. Hunter, V. Kraus, T. Sunyer, O. Nemirovskyi, B. Wyman, and R. Buck, “Clinical, radiographic, molecular and MRI-based predictors of cartilage loss in knee osteoarthritis,” Annals of the rheumatic diseases, vol. 70, no. 7, pp. 1223–1230, 2011.
  42. M. D. Crema, D. J. Hunter, F. W. Roemer, L. Li, M. D. Marra, M. H. Nogueira-Barbosa, M.-P. H. Le Graverand, B. T. Wyman, and A. Guermazi, “The relationship between prevalent medial meniscal intrasubstance signal changes and incident medial meniscal tears in women over a 1-year period assessed with 3.0 T MRI,” Skeletal radiology, vol. 40, no. 8, pp. 1017–1023, 2011.
  43. S. Cotofana, F. Eckstein, W. Wirth, R. B. Souza, X. Li, B. Wyman, M.-P. Hellio-Le Graverand, T. Link, and S. Majumdar, “In vivo measures of cartilage deformation: patterns in healthy and osteoarthritic female knees using 3T MR imaging,” European radiology, vol. 21, no. 6, pp. 1127–1135, 2011.
  44. R. Buck, B. Wyman, M.-P. H. Le Graverand, D. Hunter, E. Vignon, W. Wirth, and F. Eckstein, “Using ordered values of subregional cartilage thickness change increases sensitivity in detecting risk factors for osteoarthritis progression,” Osteoarthritis and Cartilage, vol. 19, no. 3, pp. 302–308, 2011.
  45. W. Wirth, R. B. Frobell, R. B. Souza, X. Li, B. T. Wyman, M. H. Le Graverand, T. M. Link, S. Majumdar, and F. Eckstein, “A three‐dimensional quantitative method to measure meniscus shape, position, and signal intensity using MR images: A pilot study and preliminary results in knee osteoarthritis,” Magnetic resonance in medicine, vol. 63, no. 5, pp. 1162–1171, 2010.
  46. E. Vignon, K. Brandt, C. Mercier, M. Hochberg, D. Hunter, S. Mazzuca, K. Powell, B. Wyman, and M.-P. H. Le Graverand, “Alignment of the medial tibial plateau affects the rate of joint space narrowing in the osteoarthritic knee,” Osteoarthritis and Cartilage, vol. 18, no. 11, pp. 1436–1440, 2010.
  47. R. Souza, C. Stehling, B. Wyman, M.-P. H. Le Graverand, X. Li, T. Link, and S. Majumdar, “The effects of acute loading on T1rho and T2 relaxation times of tibiofemoral articular cartilage,” Osteoarthritis and Cartilage, vol. 18, no. 12, pp. 1557–1563, 2010.
  48. M. Hudelmaier, W. Wirth, B. Wehr, V. Kraus, B. Wyman, M.-P. Hellio Le Graverand, and F. Eckstein, “Femorotibial cartilage morphology: reproducibility of different metrics and femoral regions, and sensitivity to change in disease,” Cells Tissues Organs, vol. 192, no. 5, pp. 340–350, 2010.
  49. M.-P. Hellio Le Graverand Gastineau, K. Powell, E. Vignon, R. Clemmer, and B. Wyman, “423 TECHNIQUE FOR DETERMINING OPTIMAL LYON-SCHUSS X-RAY BEAM ANGLE,” Osteoarthritis and Cartilage, vol. 18, no. 2, p. 1, 2010.
  50. M.-P. H. L. G. Gastineau, K. Powell, E. Vignon, R. Clemmer, and B. Wyman, “423 TECHNIQUE FOR DETERMINING OPTIMAL LYON-SCHUSS X-RAY BEAM ANGLE,” Osteoarthritis and Cartilage, vol. 18, pp. S188–S189, 2010.
  51. R. B. Frobell, M. C. Nevitt, M. Hudelmaier, W. Wirth, B. T. Wyman, O. Benichou, D. Dreher, R. Davies, J. H. Lee, and F. Baribaud, “Femorotibial subchondral bone area and regional cartilage thickness: A cross‐sectional description in healthy reference cases and various radiographic stages of osteoarthritis in 1,003 knees from the Osteoarthritis Initiative,” Arthritis care & research, vol. 62, no. 11, pp. 1612–1623, 2010.
  52. R. Frobell, W. Wirth, M. Nevitt, B. Wyman, O. Benichou, D. Dreher, R. Davies, J. Lee, F. Baribaud, and A. Gimona, “Presence, location, type and size of denuded areas of subchondral bone in the knee as a function of radiographic stage of OA–data from the OA initiative,” Osteoarthritis and Cartilage, vol. 18, no. 5, pp. 668–676, 2010.
  53. M. Crema, A. Guermazi, L. Li, M. Nogueira-Barbosa, M. Marra, F. Roemer, F. Eckstein, M. H. Le Graverand, B. Wyman, and D. Hunter, “The association of prevalent medial meniscal pathology with cartilage loss in the medial tibiofemoral compartment over a 2-year period,” Osteoarthritis and Cartilage, vol. 18, no. 3, pp. 336–343, 2010.
  54.  R. J. Buck, B. T. Wyman, M. H. Le Graverand, W. Wirth, F. Eckstein, and A9001140 Investigators, “An efficient subset of morphological measures for articular cartilage in the healthy and diseased human knee,” Magnetic resonance in medicine, vol. 63, no. 3, pp. 680–690, 2010.
  55. R. Buck, B. Wyman, M.-P. H. Le Graverand, M. Hudelmaier, W. Wirth, and F. Eckstein, “Osteoarthritis may not be a one-way-road of cartilage loss–comparison of spatial patterns of cartilage change between osteoarthritic and healthy knees,” Osteoarthritis and Cartilage, vol. 18, no. 3, pp. 329–335, 2010.
  56. D. M. Allen, L. Li, M. D. Crema, M. D. Marra, A. Guermazi, B. T. Wyman, M.-P. Hellio Le Graverand, M. Englund, K. D. Brandt, and D. J. Hunter, “The relationship between meniscal tears and meniscal position,” Therapeutic advances in musculoskeletal disease, vol. 2, no. 6, pp. 315–323, 2010.
  57. W. Wirth, M.-P. H. Le Graverand, B. T. Wyman, S. Maschek, M. Hudelmaier, W. Hitzl, M. Nevitt, F. Eckstein, and OAI Investigator Group, “Regional analysis of femorotibial cartilage loss in a subsample from the Osteoarthritis Initiative progression subcohort,” Osteoarthritis and cartilage, vol. 17, no. 3, pp. 291–297, 2009.
  58. B. Wehr, W. Wirth, S. Maschek, M.-P. H. Le Graverand, B. Wyman, and F. Eckstein, “414 IS PAIRED OR NON-PAIRED ANALYIS MORE EFFICIENT IN IDENTIFYING CHANGES BETWEEN BASELINE AND FOLLOW-UP MR-IMAGES IN STUDIES OF OA CARTILAGE LOSS?,” Osteoarthritis and Cartilage, vol. 17, pp. S219–S220, 2009.
  59. S. Maschek, W. Wirth, B. Wyman, M.-P. H. Le Graverand, and F. Eckstein, “409 DIFFERENCES IN QUANTITATIVE MR IMAGING OF CARTILAGE MORPHOLOGY BETWEEN SAGITTAL VERSUS CORONAL ACCQUISITIONS OF THE FEMOROTIBIAL JOINT,” Osteoarthritis and Cartilage, vol. 17, pp. S216–S217, 2009.
  60. M.-P. H. Le Graverand, R. Buck, B. Wyman, E. Vignon, S. Mazzuca, K. Brandt, M. Piperno, H. Charles, M. Hudelmaier, and D. Hunter, “Subregional femorotibial cartilage morphology in women–comparison between healthy controls and participants with different grades of radiographic knee osteoarthritis,” Osteoarthritis and Cartilage, vol. 17, no. 9, pp. 1177–1185, 2009.
  61. D. Hunter, R. Buck, E. Vignon, F. Eckstein, K. Brandt, S. Mazzuca, B. Wyman, I. Otterness, and M. H. Le Graverand, “Relation of regional articular cartilage morphometry and meniscal position by MRI to joint space width in knee radiographs,” Osteoarthritis and Cartilage, vol. 17, no. 9, pp. 1170–1176, 2009.
  62. R. Frobell, R. Souza, B. Wyman, W. Wirth, M.-P. Hellio-LeGraverand, M. Hedelmaier, X. Li, T. Link, F. Eckstein, and S. Majumdar, “MENISCUS SHAPE, POSITION, AND SIGNAL UNDER SIMULATED WEIGHTBEARING AND NON-WEIGHTBEARING CONDITIONS IN VIVO,” Osteoarthritis and Cartilage, vol. 17, pp. S236–S237, 2009.
  63. F. Eckstein, B. T. Wyman, R. J. Buck, W. Wirth, S. Maschek, M. Hudelmaier, and M. Hellio Le Graverand, “Longitudinal quantitative MR imaging of cartilage morphology in the presence of gadopentetate dimeglumine (Gd‐DTPA),” Magnetic Resonance in Medicine: An Official Journal of the International Society for Magnetic Resonance in Medicine, vol. 61, no. 4, pp. 975–980, 2009.
  64. F. Eckstein, W. Wirth, M. I. Hudelmaier, S. Maschek, W. Hitzl, B. T. Wyman, M. Nevitt, M.-P. H. Le Graverand, and D. Hunter, “Relationship of compartment-specific structural knee status at baseline with change in cartilage morphology: a prospective observational study using data from the osteoarthritis initiative,” Arthritis Research and Therapy, vol. 11, no. 3, p. R90, 2009.
  65. F. Eckstein, S. Maschek, W. Wirth, M. Hudelmaier, W. Hitzl, B. Wyman, M. Nevitt, M. H. Le Graverand, and OAI Investigator Group, “One year change of knee cartilage morphology in the first release of participants from the Osteoarthritis Initiative progression subcohort: association with sex, body mass index, symptoms and radiographic osteoarthritis status,” Annals of the rheumatic diseases, vol. 68, no. 5, pp. 674–679, 2009.
  66. F. Eckstein, M.-P. H. Le Graverand, C. Charles, D. Hunter, V. Kraus, O. Nemirovskyi, T. Sunyer, E. Vignon, B. Wyman, and R. Buck, “WHICH BASELINE FACTORS PREDICT CARTILAGE THINNING AND THICKENING IN OA KNEES-RESULTS FROM THE A9001140 STUDY,” Osteoarthritis and Cartilage, vol. 17, pp. S215–S216, 2009.
  67. S. Cotofana, R. Frobell, B. Wyman, O. Benichou, D. Dreher, R. Davies, M. Nevitt, J. Lee, F. Baribaud, and W. Wirth, “RELATIONSHIP OF WEIGHT-BEARING AND NON-WEIGHT-BEARING PAIN IN KNEE OA WITH (CENTRAL) FEMOROTIBIAL DENUDED AREAS-DATA FROM THE OA INITIATIVE,” Osteoarthritis and Cartilage, vol. 17, pp. S41–S42, 2009.
  68. R. J. Buck, B. T. Wyman, M. hellio Le Graverand, M. Hudelmaier, W. Wirth, F. Eckstein, and A9001140 Investigators, “Does the use of ordered values of subregional change in cartilage thickness improve the detection of disease progression in longitudinal studies of osteoarthritis?,” Arthritis Care & Research, vol. 61, no. 7, pp. 917–924, 2009.
  69. B. Wyman, R. Buck, E. Vignon, A. Brett, and M. G. Le-Graverand, “COMPARISON OF ONE YEAR CHANGE IN MINIMUM JOINT SPACE WIDTH TO FIXED LOCATION JOINT SPACE MEASUREMENTS IN LYON SCHUSS X-RAYS FROM THE A9001140 STUDY,” Osteoarthritis and Cartilage, vol. 16, pp. S164–S165, 2008.
  70. B. Wehr, M. Hudelmaier, W. Wirth, V. Kraus, C. Charles, B. Wyman, M. H. Le Graverand, and F. Eckstein, “PRECISION AND SENSITIVITY TO CHANGE FOR DIFFERENT METRICS AND REGIONS OF FEMOROTIBIAL CARTILAGE MORPHOLOGY,” Osteoarthritis and Cartilage, vol. 16, p. S171, 2008.
  71. H. R. Underhill, V. L. Yarnykh, T. S. Hatsukami, J. Wang, N. Balu, C. E. Hayes, M. Oikawa, W. Yu, D. Xu, and B. Chu, “Carotid plaque morphology and composition: initial comparison between 1.5-and 3.0-T magnetic field strengths,” Radiology, vol. 248, no. 2, pp. 550–560, 2008.
  72. S. Maschek, W. Wirth, B. Wyman, R. Buck, M. Hudelmaier, M. H. Le Graverand, and F. Eckstein, “IMPACT OF THE CONTRAST AGENT GADOPENTATE DIMEGLUMINE ON QUANTITATIVE MAGNETIC RESONANCE IMAGING OF CARTILAGE MORPHOLOGY,” Osteoarthritis and Cartilage, vol. 16, p. S174, 2008.
  73. M. H. Le Graverand, B. Wyman, R. Buck, M. Hudelmaier, and F. Eckstein, “TWO YEAR LONGITUDINAL CHANGES IN REGIONAL CARTILAGE MORPHOLOGY IN A MULTICENTER MULTIVENDOR MRI STUDY AT 3.0 T–THE A9001140 STUDY,” Osteoarthritis and Cartilage, vol. 16, p. S178, 2008.
  74. M. H. Le Graverand, E. P. Vignon, K. D. Brandt, S. A. Mazzuca, M. Piperno, R. Buck, H. C. Charles, D. J. Hunter, C. G. Jackson, and V. B. Kraus, “Head-to-head comparison of the Lyon Schuss and fixed flexion radiographic techniques. Long-term reproducibility in normal knees and sensitivity to change in osteoarthritic knees,” Annals of the rheumatic diseases, vol. 67, no. 11, pp. 1562–1566, 2008.
  75. M.-P. H. Le Graverand, R. J. Buck, B. T. Wyman, E. Vignon, S. A. Mazzuca, K. D. Brandt, M. Piperno, H. C. Charles, M. Hudelmaier, and D. J. Hunter, “Change in regional cartilage morphology and joint space width in osteoarthritis participants versus healthy controls–a multicenter study using 3.0 Tesla MRI and Lyon Schuss radiography,” Annals of the rheumatic diseases, 2008.
  76. D. Hunter, R. Buck, E. Vignon, F. Eckstein, K. Brandt, S. Mazzuca, B. Wyman, I. Otterness, and M. H. Le Graverand, “RELATION OF REGIONAL ARTICULAR CARTILAGE MORPHOMETRY AND MENISCAL POSITION BY MRI TO JSW IN KNEE RADIOGRAPHS,” Osteoarthritis and Cartilage, vol. 16, p. S172, 2008.
  77. M. Hellio Le Graverand, B. Wyman, R. Buck, M. Hudelmaier, and F. Eckstein, “TWO YEAR LONGITUDINAL CHANGES IN REGIONAL CARTILAGE MORPHOLOGY IN A MULTICENTER MULTIVENDOR MRI STUDY AT 3.0 T THE A9001140 STUDY,” Osteoarthritis and Cartilage, vol. 16, no. 4, p. 1, 2008.
  78. F. Eckstein, R. J. Buck, D. Burstein, H. C. Charles, J. Crim, M. Hudelmaier, D. Hunter, G. Hutchins, C. Jackson, and V. B. Kraus, “Precision of 3.0 Tesla quantitative magnetic resonance imaging of cartilage morphology in a multicentre clinical trial,” Annals of the rheumatic diseases, vol. 67, no. 12, pp. 1683–1688, 2008.
  79.  R. Buck, F. Eckstein, B. Wyman, and M. H. Le Graverand, “LOCATION AND MAGNITUDE OF CARTILAGE THICKNESS LOSS IN OA PROGRESSORS,” Osteoarthritis and Cartilage, vol. 16, p. S182, 2008.
  80. W. Wirth, S. Maschek, M.-P. H. Le Graverand, B. Wyman, M. Hudelmaier, M. Nevitt, and F. Eckstein, “SENSITIVITY TO CHANGE OF CARTILAGE THICKNESS FOR DIFFERENT SUBREGIONS OF THE KNEE–DATA FROM THE OSTEOARTHRITIS INITIATIVE PROGRESSION SUBCOHORT,” Osteoarthritis and Cartilage, vol. 15, pp. C27–C28, 2007.
  81. E. Vignon, K. Brandt, S. Mazzuca, R. Buck, B. Wyman, M. Tengowski, and M.-P. H. Le Graverand, “DOES INCREASING OBESITY INCREASE THE PROGRESSION OF KNEE OSTEOARTHRITIS?,” Osteoarthritis and Cartilage, vol. 15, p. C147, 2007.
  82. T. Saam, T. S. Hatsukami, V. L. Yarnykh, C. E. Hayes, H. Underhill, B. Chu, N. Takaya, J. Cai, W. S. Kerwin, and D. Xu, “Reader and platform reproducibility for quantitative assessment of carotid atherosclerotic plaque using 1.5 T Siemens, Philips, and General Electric scanners,” Journal of Magnetic Resonance Imaging, vol. 26, no. 2, pp. 344–352, 2007.
  83. S. Maschek, W. Wirth, M.-P. H. Le Graverand, B. Wyman, M. Hudelmaier, W. Hitzl, M. Nevitt, and F. Eckstein, “CARTILAGE THICKNESS CHANGES IN THE KNEE OVER 1 YEAR AND ASSOCIATED RISK FACTORS–DATA FROM THE OSTEOARTHRITIS INITIATIVE PROGRESSION SUBCOHORT,” Osteoarthritis and Cartilage, vol. 15, p. C166, 2007.
  84. M.-P. H. Le Graverand, B. Wyman, R. Buck, W. Wirth, M. Hudelmaier, and F. Eckstein, “TWELVE MONTH LONGITUDINAL CHANGE IN REGIONAL CARTILAGE MORPHOLOGY IN A MULTICENTER, MULTIVENDOR MRI STUDY AT 3.0 TESLA–THE A9001140 STUDY,” Osteoarthritis and Cartilage, vol. 15, p. C172, 2007.
  85. F. Eckstein, R. J. Buck, B. T. Wyman, J. J. Kotyk, M. H. Le Graverand, A. E. Remmers, J. L. Evelhoch, M. Hudelmaier, and H. C. Charles, “Quantitative imaging of cartilage morphology at 3.0 Tesla in the presence of gadopentate dimeglumine (Gd‐DTPA),” Magnetic Resonance in Medicine: An Official Journal of the International Society for Magnetic Resonance in Medicine, vol. 58, no. 2, pp. 402–406, 2007.
  86. F. Eckstein, S. Maschek, W. Wirth, B. Wyman, M. Hudelmaier, and M. Nevitt, “Change in femorotibial cartilage volume and subregional cartilage thickness over 1 year–data from the osteoarthritis initiative progression subcohort,” Arthritis Rheum, vol. 56, no. 9S, p. S283, 2007.
  87. B. Wyman, “14 REGULATORY ASPECTS OF IMPLEMENTING IMAGING BIOMARKERS,” Osteoarthritis and Cartilage, vol. 14, p. S6, 2006.
  88. T. Tuthill, D. Raunig, A. Hickman, B. Peterson, and B. Wyman, “MRI Quantification of Liver Fat in an Obese Population,” 2006, vol. 14, p. 2295.
  89. M. H. Le Graverand, S. Mazzuca, S. Totterman, J. Tamez, R. Buck, B. Wyman, M. Tengowski, and E. Vignon, “P257 BASELINE BONE MARROW LESIONS, BUT NOT SYNOVIAL FLUID EFFUSION, PREDICT JOINT SPACE NARROWING AT 1 YEAR,” Osteoarthritis and Cartilage, vol. 14, p. S139, 2006.
  90. M. H. Le Graverand, R. Buck, B. Wyman, and F. Eckstein, “P280 KNEE CARTILAGE MORPHOLOGY IN RELATION TO RADIOGRAPHIC OSTEOARTHRITIS STATUS: A CROSS-SECTIONAL STUDY USING 3 TESLA MR IMAGING,” Osteoarthritis and Cartilage, vol. 14, p. S153, 2006.
  91. M. H. Le Graverand, R. Buck, B. Wyman, M. Tengowski, and E. Vignon, “P256 HEAD TO HEAD COMPARISON OF THE LYON SCHUSS AND THE FIXED FLEXION RADIOGRAPH TECHNIQUES. LONG-TERM REPRODUCIBILITY IN NORMAL KNEES AND SENSITIVITY TO CHANGE IN OSTEOARTHRITIC KNEES,” Osteoarthritis and Cartilage, vol. 14, pp. S138–S139, 2006.
  92. J Gee, T. Sundaram, B. Avants, P. Burstein, P. Yushkevich, H. Zhang, I. Casselbrant, P. Akeson, G. Pettersson, and B. Wyman, “Quantitation of Pulmonary Structure via Registration and Normalization of Serial 3He MR Images,” 2006, vol. 14, p. 1326.
  93. F. Eckstein, C. Charles, M. Hudelmaier, R. Buck, B. Wyman, and M.-P. H. Le Graverand, “A20 PRECISION OF 3 TESLA MR IMAGING OF CARTILAGE MORPHOLOGY IN A MULTICENTER CLINICAL TRIAL,” Osteoarthritis and Cartilage, vol. 14, p. S27, 2006.
  94. C. L. Stork and B. T. Wyman, “Convolution filtering of similarity data for visual display of enhanced image,” Jan. 2004.
  95. B. T. Wyman, C. L. Stork, J. P. Smith, R. E. Price, P. R. Gavin, R. L. Tucker, E. R. Wisner, J. S. Mattoon, and J. D. Hazle, “Improved detection of metastases on magnetic resonance images by digital tissue recognition: Validation using VX‐2 tumor in the rabbit,” Journal of Magnetic Resonance Imaging: An Official Journal of the International Society for Magnetic Resonance in Medicine, vol. 18, no. 2, pp. 232–241, 2003.
  96. J. M. Sorger, B. T. Wyman, O. P. Faris, W. C. Hunter, and E. R. McVeigh, “Torsion of the left ventricle during pacing with MRI tagging,” Journal of Cardiovascular Magnetic Resonance, vol. 5, no. 4, pp. 521–530, 2003.
  97. S. D. Pathak, L. Ng, B. Wyman, S. Fogarasi, S. Racki, J. C. Oelund, B. Sparks, and V. Chalana, “Quantitative image analysis: software systems in drug development trials,” Drug discovery today, vol. 8, no. 10, pp. 451–458, 2003.
  98. B. T. Wyman, W. C. Hunter, F. W. Prinzen, O. P. Faris, and E. R. McVeigh, “Effects of single-and biventricular pacing on temporal and spatial dynamics of ventricular contraction,” American Journal of Physiology-Heart and Circulatory Physiology, vol. 282, no. 1, pp. H372–H379, 2002.
  99. C. Stork, J. Smith, R. Price, P. Gavin, J. Hazle, and B. Wyman, “Improved detection of metastases on magnetic resonance images by tissue segmentation analysis: Validation using VX-2 tumor in the rabbit,” 2001, vol. 221, pp. 157–157.
  100. A. Samli, C. Ozturk, O. Faris, and B. Wyman, “Analysis of the activation propagation on both ventricles using tagged mri,” 2001, vol. 1, pp. 307–310.
  101. B. T. Wyman, C. L. Stork, R. E. Price, J. D. Hazle, P. Gavin, R. Tucker, and J. Smith, “Evaluation of automatic guided specific tissue segmentation using VX-2 tumor in the rabbit,” 2000, p. 581.
  102.  J. M. Sorger, B. T. Wyman, O. P. Faris, W. R. Hunter, and E. R. McVeigh, “Torsion of the left ventricle during pacing with MRI tagging,” 2000, vol. 3978, pp. 217–224.
  103. J. Sorger, B. Wyman, O. Faris, W. Hunter, and E. McVeigh, “Torsion of the left ventricle during pacing with MRI tagging [3978-23],” 2000, pp. 217–224.
  104. F. Prinzen, B. Wyman, W. Hunter, O. Faris, and E. McVeigh, “Effects of single and bi-ventricular facing on the temporal and spatial dynamics of ventricular contraction,” 2000, vol. 102, no. 18, pp. 161–162.
  105. G. S. Nelson, C. W. Curry, B. T. Wyman, A. Kramer, J. Declerck, M. Talbot, M. R. Douglas, R. D. Berger, E. R. McVeigh, and D. A. Kass, “Predictors of systolic augmentation from left ventricular preexcitation in patients with dilated cardiomyopathy and intraventricular conduction delay,” Circulation, vol. 101, no. 23, pp. 2703–2709, 2000.
  106. G. S. Nelson, C. W. Curry, B. T. Wyman, A. Kramer, J. Declerck, M. Talbot, M. R. Douglas, R. D. Berger, E. R. McVeigh, and D. A. Kass, “Clinical Investigation and Reports-Predictors of Systolic Augmentation From Left Ventricular Preexcitation in Patients With Dilated Cardiomyopathy and Intraventricular Conduction Delay,” Circulation-Hagertown, vol. 101, no. 23, pp. 2703–2709, 2000.
  107. C. W. Curry, G. S. Nelson, B. T. Wyman, J. Declerck, M. Talbot, R. D. Berger, E. R. McVeigh, and D. A. Kass, “Mechanical dyssynchrony in dilated cardiomyopathy with intraventricular conduction delay as depicted by 3D tagged magnetic resonance imaging,” Circulation, vol. 101, no. 1, pp. e2–e2, 2000.
  108. B. T. Wyman, W. C. Hunter, F. W. Prinzen, and E. R. McVeigh, “Mapping propagation of mechanical activation in the paced heart with MRI tagging,” American Journal of Physiology-Heart and Circulatory Physiology, vol. 276, no. 3, pp. H881–H891, 1999.
  109. B. T. Wyman, “Mechanical evaluation of the paced heart using tagged magnetic resonance imaging,” 1999.
  110. F. W. Prinzen, W. C. Hunter, B. T. Wyman, and E. R. McVeigh, “Mapping of regional myocardial strain and work during ventricular pacing: experimental study using magnetic resonance imaging tagging,” Journal of the American College of Cardiology, vol. 33, no. 6, pp. 1735–1742, 1999.
  111. F. W. Prinzen, W. C. Hunter, B. T. Wyman, and E. R. McVeigh, “EXPERIMENTAL STUDIES-Mapping of Regional Myocardial Strain and Work During Ventricular Pacing Experimental Study Using Magnetic Resonance Imaging Tagging,” Journal of the American College of Cardiology, vol. 33, no. 6, pp. 1735–1742, 1999.
  112.  I. Oznur, E. McVeigh, B. Wyman, J. Lima, D. Bluemke, and D. Kraitchman, “Detection of viable myocardium with MRI after ischemic injury,” 1998, vol. 98, no. 17, pp. 857–858.
  113. I. Oznur, D. Kraitchman, B. Wyman, D. Bluemke, and E. McVeigh, “Myocardial viability detection after myocardial stunning using 3D tagged MRI,” 1998, vol. 209, pp. 229–229.
  114. E. R. McVeigh, F. W. Prinzen, B. T. Wyman, J. E. Tsitlik, H. R. Halperin, and W. C. Hunter, “Imaging asynchronous mechanical activation of the paced heart with tagged MRI,” Magnetic resonance in medicine, vol. 39, no. 4, pp. 507–513, 1998.
  115. C. Curry, B. Fetics, B. Wyman, E. McVeigh, and D. Kass, “Mechanical dyssynchrony at rest and with adrenergic stimulation in patients with dilated cardiomyopathy studied by MRI-tagging: Can it help identify candidates for chronic VDD pacing therapy?,” 1998, vol. 98, no. 17, pp. 302–302.
  116. S. E. Keilson, V. M. Richards, B. T. Wyman, and E. D. Young, “The representation of concurrent vowels in the cat anesthetized ventral cochlear nucleus: evidence for a periodicity-tagged spectral representation,” The Journal of the Acoustical Society of America, vol. 102, no. 2, pp. 1056–1071, 1997.
  117. B. Wyman, S. Hendrix, S. Hennessey, S. Dickson, J. Groves, W. Croft, D. Adams, “Impact of specialized light therapy in Parkinson’s disease on MDS-UPDRS parts 1-3 subscales,” International Parkinson and Movement Disorder Society, Mov Disord. 2021; 36 (suppl 1).